王宇,博士,副教授,硕士生导师
联系方式:wangyu@jxau.edu.cn
教育及工作经历
2008-2012 天津科技大学,本科
2012-2017 南开大学,博士
2017-2019 上海科技大学,博士后
2019-2022 yl23455永利官方,讲师
2022-至今 yl23455永利官方,副教授
研究方向
(1)病原细菌新型基因组编辑工具开发
(2)病原细菌耐药及致病机制研究
主持课题
(1)中国博士后基金项目,金黄色葡萄球菌中高效同源重组系统的筛选与应用(2018M632190),2018.06-2019.08,5万元,主持,结题
(2)江西省教育厅项目,基于单碱基编辑技术筛选鲍曼不动杆菌中的必需基因(GJJ190239),2020.01-2022.12,2万元,主持,结题
(3)河南省工业微生物资源与发酵技术重点实验室开放课题,河南地区油脂酵母属Lipomyces的分类学研究和功能菌鉴定(HIMFT20200101),2020.10-2022.10,2万元,主持,结题
(4)江西省科技厅项目,鲍曼不动杆菌rosf-1基因影响致病能力的机制研究(20202BABL213040),2021.01-2022.12,6万元,主持,结题
(5)国家自然科学青年基金,2021.01-2023.12,鲍曼不动杆菌Rosf-1蛋白在活性氧应答中的功能及机制研究(32000100),24万元,主持,在研
发表论文
(1)Wang Y, Wang S, Chen W, et al. CRISPR-Cas9 and CRISPR-assisted cytidine deaminase enable precise and efficient genome editing in Klebsiella pneumoniae[J].Applied and Environmental Microbiology, 2018, 84(23): e01834-18.
(2)Sun Q#, Wang Y#, Dong N, et al. The application of CRISPR/Cas9-based genome editing in studying the mechanism of pandrug resistance in Klebsiella pneumoniae[J]. Antimicrobial Agents and Chemotherapy, 2019: AAC. 00113-19.
(3)Wang Y, Wang Z, Chen Y, et al. A highly efficient CRISPR-Cas9-based genome engineering platform in Acinetobacter baumannii to understand the H2O2-sensing mechanism of OxyR[J].Cell Chemical Biology, 2019, 26(12): 1732-1742.
(4)Wang Y, Wang Z, Ji Q. CRISPR-Cas9-based genome editing and Cytidine Base editing in Acinetobacter baumannii[J]. STAR protocols, 2020, 1(1): 100025.
(5)Yang C#, Yang M#, Zhao W, Ding Y, Wang Y*, & Li J*. Establishing a Klebsiella pneumoniae-Based Cell-Free Protein Synthesis System[J]. Molecules, 2022, 27(15): e4684.
(5)Li M, Weng S, Wang Q, Yang Z, Wang X, Yin Y, Zhou Q, Zhang L, Tao F, Li Y, Jia M, Yang L, Xin X, Li H, Kang L, Wang Y*, Wang T*, Li S*, Kong L*. Reduced binding activity of vaccine serum to omicron receptor-binding domain[J]. Frontiers in immunology, 2022, 13: 960195.
(6)Yang L, Wang R, Zhang Y, Wang Y*, Rong H*. The complete mitochondrial genome and phylogenetic analysis of Polythlipta liquidalis Leech, 1889 (Crambidae: spilomelinae)[J]. Mitochondrial DNA Part B, 2023, 8(10): 1063-1066.
(7)杨领弟, 李小梅, 芦晓鸥, 彭棋, 孔令保*, 王宇*.猴痘病毒B20R蛋白原核表达及其多克隆抗体的制备[J/OL].南方农业学报, 2023, http://kns.cnki.net/kcms/detail/45.1381.S.20231122.1334.002.html.
(8)Wang S, Ding Y, Rong H*, Wang Y*. The Development of a CRISPR-FnCpf1 System for Large-Fragment Deletion and Multiplex Gene Editing in Acinetobacter baumannii[J]. Current Issues in Molecular Biology, 2024, 46(1): 570-584.